Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. |
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| Authors: | S C Penna M V Medeiros F S C Aimbire H C C Faria-Neto J A A Sertié R A B Lopes-Martins |
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| Institution: | 1. Laboratório de Farmacologia e Experimentação Animal, Instituto de Pesquisa e Desenvolvimento – IP&D, Universidade do Vale do Paraíba – UNIVAP, Urbanova, São José dos Campos;2. Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil;3. Departamento de Fisiologia e Farmacodinâmica, Fundação Oswaldo Cruz – Av. Brasil – Manguinhos;1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China;2. Center for Disease Control and Prevention, Jinan Military Region, PLA, Ji?nan 250014, PR China;3. Department of Pharmaceutical analysis, School of Pharmacy, NingXia Medical University, 1160 Shenli Street, Yinchuan 750004, PR China;4. Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK;1. Shaanxi Spine Medicine Research Center, Hong Hui Hospital, Xi''an Jiaotong University College of Medicine, Shaanxi, China;2. Department of Spine Surgery, Hong Hui Hospital, Xi''an Jiaotong University College of Medicine, 710054, Shaanxi, China;3. Translational Medicine Center, Hong Hui Hospital, Xi''an Jiaotong University College of Medicine, 710054, Shaanxi, China;4. Institute of Neurosciences, The Fourth Military Medical University, 710032, Shaanxi, China;5. Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Medical Center, 92354, Loma Linda, CA, USA |
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| Abstract: | Plant extracts have been used for centuries as a popular mode of treatment for several health disorders. Over the last ten years, the study of those extracts has attracted attention in different fields of the biological sciences. Ginger, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), is a commom constituent of diet worldwide and it has been reported that its extracts present some pharmacological activities. Here we investigate the effects of the crude hydralcoholic extract of ginger rhizomes on the classical models of rat paw and skin edema. The carrageenan-, compound 48/80- or serotonin-induced rat paw edema were inhibited significantly by the intraperitoneal administration of alcoholic ginger extract. Ginger extract was also effective in inhibiting 48/80-induced rat skin edema at doses of 0.6 and 1.8 mg/site. Rat skin edema induced by substance P or bradikinin was not affected by treatment with Z. officinalle extract. The intraperitoneal administration of ginger extract (186 mg/kg(-1) body wt.) 1 h prior to serotonin injections, reduced significantly the serotonin-induced rat skin edema. Our results demonstrated that crude extract of Zingiber officinale was able to reduce rat paw and skin edema induced by carrageenan, 48/80 compound and serotonin. The antiedematogenic activity seems to be related, at least partially, to an antagonism of the serotonin receptor. |
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