A genetic linkage map of the rat derived from recombinant inbred strains |
| |
| Authors: | M. Pravenec D. Gauguier J. -J. Schott J. Buard V. Křen V. Bílá C. Szpirer J. Szpirer J. -M. Wang H. Huang E. St.Lezin M. A. Spence P. Flodman M. Printz G. M. Lathrop G. Vergnaud T. W. Kurtz |
| |
| Affiliation: | (1) Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic, CS;(2) Laboratoire de Genetique Moleculaire, Centre d'Etudes du Bouchet, Vert le Petit, France, FR;(3) Wellcome Trust Centre for Human Genetics, Oxford, UK, GB;(4) Laboratoire de Genetique des Especes, Institut de Biologie, Nantes, France, FR;(5) Department of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic, CS;(6) Department of Molecular Biology, Universite Libre de Bruxelles, Rhode-St-Genese, Belgium, BE;(7) Department of Laboratory Medicine, University of California, San Francisco, California, USA, US;(8) Department of Pediatrics, University of California, Irvine, California, USA, US;(9) Department of Pharmacology, University of California, San Diego, California, USA, US;(10) INSERM U358, Hopital St. Louis, Paris, France, FR |
| |
| Abstract: | We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains. Received: 21 June 1995 / Accepted: 11 September 1995 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
