Involvement of the serotonergic cerebral system in microwave-induced analgesia in mice of different genotypes |
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Authors: | E V Bagatskaya |
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Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
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Abstract: | Under conditions of the formalin test, we studied changes in the level of analgesia induced by the action of low-intensity
microwaves on the antinociceptive acupuncture point (AP) E36 in mice of strains CBA/CaLac (CBA) and C57BL/6j (C57) and in
albino mongrel mice. Measurements were performed under control conditions and with experimentally induced decrease in the
serotonin level in the brain (by injections of DL-parachlorophenylalanine, p-CPA). In the latter cases, the duration of the pain behavioral reaction increased despite irradiation of the AP E36. In mongrel,
CBA, and C57 mice, the intensity of pain manifestations was 114.4, 29.0, and 21.1% greater, respectively, than in mice of
these groups with no injections of p-CPA. These facts show that the serotonergic brain system is profoundly involved in the formation of analgesia after irradiation
of the AP by low-intensity microwaves, and this involvement significantly depends on the genotype of the animals.
Neirofiziologiya/Neurophysiology, Vol. 38, Nos. 5/6, pp. 495–497, September–December, 2006. |
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Keywords: | pure strains low-intensity microwaves acupuncture points analgesia DL-parachlorophe nylalanine |
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