Evolution of the MIP family of integral membrane transport proteins |
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| Authors: | G M Pao L-F Wu K D Johnson H Höfte M J Chrispeels G Sweet N N Sandal M H Saier Jr |
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| Institution: | Department of Biology, 0116, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0116, USA.;Department of Biology, University of Konstanz, D-7750 Konstanz, Germany.;Department of Molecular Biology and Plant Physiology, University of Aarhus, DK-8000 Aarhus C, Denmark. |
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| Abstract: | Six integral membrane proteins of bacterial, animal, and plant origin, which are believed to function in solute transport, share sequence identity and are grouped together as members of the MIP family. These include the Escherichia coli glycerol facilitator, the major intrinsic protein from bovine lens fibre junction membranes, a plant tonoplast membrane protein, a soybean protein from the peribacteroid membrane, and a Drosophila neurogenic protein. These proteins, each of which appears to consist of six transmembrane helical segments per subunit, apparently arose by internal duplication of a three-transmembrane segment. Phylogenetic‘trees’interrelating these proteins and segments are presented. |
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