Genetic polymorphism of the sixth component of complement (C6) in the pig |
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Authors: | T Shibata T Abe T Akita |
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Institution: | Laboratory of Animal Breeding, Kyushu Tokai University, Aso-gun, Kumamoto 869–14, Japan;National Institute of Animal Industry, Tsukuba, Japan |
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Abstract: | Summary Using agarose gel isoelectric focusing and immunoblotting with rabbit anti-rabbit C6, a genetic polymorphism has been found in the sixth component of complement (C6) in six breeds of pigs. The C6 locus was highly polymorphic. Family data indicated that pig C6 pheno-types were inherited by means of five codomonant alleles named C6 A, C6 B, C6 C, C6 D and C6 E at a single autosomal locus. C6 deficiency in two of 241 individuals tested was found, which suggested the presence of a null allele in pig populations. Marked breed differences among the gene frequencies and heterozygosities at C6 locus were observed. |
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Keywords: | pig C6 genetic polymorphism immunoblotting |
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