Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates |
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| Authors: | Howard J Cooke Jorg Schmidtke John R Gosden |
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| Institution: | (1) MRC Mammalian Genome Unit King's Buildings, West Mains Road, EH9 3JT Edinburgh, Scotland;(2) Institut für Humangenetik, Universität Göttingen, Nikolausberger Weg 5a, D-3400 Göttingen, Germany;(3) MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, EH4 2XU Edinburgh, Scotland |
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| Abstract: | The human Y chromosome carries 2000 copies of a tandemly repeated sequence, 2.47 kb long, which constitutes about 20% of the DNA of this chromosome. These sequences are localised on the tip of the long arm of the Y chromosome. Related sequences are present in DNA of females with a related but distinguishable restriction pattern. These autosomal sequences are distributed in tandem arrays on a number of autosomes. Related sequences are also present in gorilla and chimpanzee. In gorilla they resemble the human sequences in their restriction map but are not found on the Y chromosome whereas in chimpanzee the related sequences behave as a  dispersed repeat. Changes in the level of methylation of this sequence in different tissues of human males can be detected with the lowest levels found in sperm and placental DNA. |
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