Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus |
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| Authors: | Fortwendel Jarrod R Juvvadi Praveen R Rogg Luise E Steinbach William J |
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| Institution: | 1Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina;2Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina |
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| Abstract: | Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi. |
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