Growth inhibition of Helicobacter pylori by apolyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone) |
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| Authors: | S Takaji H Hibasami I Imoto Y Hashimoto K Nakao N Ikemura Y Taguchi & K Nakashima |
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| Institution: | Third Department of Internal Medicine,;Department of Biochemistry, Faculty of Medicine,;College of Medical Sciences, Mie University, Tsu-city, Mie, Japan |
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| Abstract: | The anti-proliferative effect of methylglyoxal bis(cyclopentyl-amidino-hydrazone) (MGBCP), a multi-enzyme inhibitor of polyamine biosynthesis, on the growth of Helicobacter pylori was investigated. MGBCP inhibited the cell growth of H. pylori in a dose-dependent manner. The inhibition was partially reversed by the addition of spermidine. Synthesis of macromolecules, DNA, RNA and protein, was inhibited in the spermidine-depleted H. pylori cells. These findings suggest that MGBCP exhibits an anti-proliferative effect on H. pylori by suppression of macromolecule synthesis. |
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