Influence of dietary supplementation with thiamine on lead intoxication in rats |
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Authors: | S J S Flora R P Sharma |
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Institution: | (1) Center for Environmental Toxicology, Utah State University, 84322-4620 Logan, UT |
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Abstract: | The influence of dietary supplementation with thiamine on lead (Pb) contents in blood and tissues, blood δ-aminolevulinic
acid dehydratase (δ-ALAD) activity, and urinary excretion of δ-aminolevulinic acid (δ-ALA) was evaluated in male Sprague-Dawley
rats. Groups of randomly selected animals were given a thiamine-deficient diet, a diet containing normal thiamine (20 mg/kg),
or a thiamine-supplemented diet (50 mg/kg), along with control drinking water or water containing 100 ppm Pb, for 4 mo. Animals
fed the thiamine-supplemented diet (50 mg/kg) and Pb showed decreased urinary excretion of δ-ALA and a decreased inhibition
of δ-ALAD activity in blood compared to those given Pb with normal thiamine diet. The liver, kidney, and blood of rats receiving
supplemental thiamine also contained significantly less Pb than the other two treatment groups given Pb-containing water.
The protective effect of thiamine against Pb toxicity may be attributed to its interference with retention of the metal in
body tissue, possibly resulting from the formation of excretable thiamine-lead complexes. |
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Keywords: | Lead thiamine in lead intoxication thiamine diatary supplementation of δ -aminolevulinic acid dehydratase activity of and urinary excretion of thiamine-lead interaction of δ -aminolevulinic acid |
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