Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell |
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| Authors: | Li Tang Yu Zhang Hong Pan Qiong Luo Xiao-Ming Zhu Min-Yue Dong Peter CK Leung Jian-Zhong Sheng He-Feng Huang |
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| Institution: | (1) Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China;(2) Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China;(3) Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, V6H 3V5 Vancouver, British Columbia, Canada;(4) Department of Reproductive Endocrinology, The First People's Hospital of Yunnan Province, Yunnan, China |
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| Abstract: | Background Progesterone plays an important role in the proliferation and differentiation of human endometrial cells (hECs). Large-dose
treatment with progesterone has been used for treatment of endometrial proliferative disorders. However, the mechanisms behind
remain unknown. |
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