Injection of colorectal cancer cells in mesenteric and antimesenteric sides of the colon results in different patterns of metastatic diffusion: An experimental study in rats |
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Authors: | Luigi Boni Angelo Benevento Gianlorenzo Dionigi Francesca Rovera Mario Diurni Renzo Dionigi |
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Institution: | 2. Division of Clinical Research, Instituto Nacional de Cancerología, Mexico 1. Division of Internal Medicine, Instituto Nacional de Cancerología, Mexico 5. Genetic Pathology Evaluation Center of the Departments of Pathology, British Columbia Cancer Agency Vancouver, Canada 6. General Hospital and University of British Columbia and the Prostate Centre at the Vancouver General Hospital, Vancouver, British Columbia, Canada 4. Unidad de Investigacion Biomédica en Cancer, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico e Instituto Nacional de Cancerología, Mexico 3. Division of Pathology, Instituto Nacional de Cancerología, Mexico
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Abstract: | Background Parathyroid carcinoma is a rare malignancy, with an incidence of 0.5 to 4% of all cases of primary hyperparathyroidism. Surgery is the only curative treatment. Case presentation We report the case of a 66-year-old man referred for a large suspicious substernal goitre associated with severe hypercalcemia due to hyperparathyroidism. After normalization of serum calcium levels, patient underwent surgery. The voluminous cervicomediastinal firm mass could not be removed through the cervical incision; therefore a cervicothoracic approach was employed. Histopathology revealed a giant parathyroid cancer of 450 grams. A review of the literature was also undertaken to summarize the current treatment approaches for this rare malignancy. Conclusion Parathyroid cancer is usually not recognized either preoperatively or intra-operatively. En bloc resection of the tumour with the adjacent tissue is the treatment of choice and it is very important to avoid the rupture of the capsule during operation. Neither tumour size, nor the lymph node status appears to play a role in prognosis. The management of parathyroid carcinoma is a challenge even for experienced surgeons. |
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