Role of Nrf2 in the pathogenesis of atherosclerosis |
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| Institution: | 1. Department of Molecular Biology, Institute for Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan;2. Department of Neurology, Shioda Hospital, Idemizu 1221, Katsuura-Shi, Chiba, Japan;3. Division of Internal Medicine, Kaihin Park Clinic, 2-1-2-5 Utase, Mihama-ku, Chiba-city, Chiba, 261-0013, Japan;4. Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan |
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| Abstract: | Atherosclerosis is a chronic inflammatory disease of the vascular arterial walls. A number of studies have revealed the biological and genetic bases of atherosclerosis, and over 100 genes influence atherosclerosis development. Nrf2 plays an important role in oxidative stress response and drug metabolism, but the Nrf2 signaling pathway is closely associated with atherosclerosis development. During atherosclerosis progression, Nrf2 signaling modulates many physiological and pathophysiological processes, such as lipid homeostasis regulation, foam cell formation, macrophage polarization, redox regulation and inflammation. Interestingly, Nrf2 exhibits both pro- and anti-atherogenic effects in experimental animal models. These observations make the Nrf2 pathway a promising target to prevent atherosclerosis. |
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| Keywords: | Atherosclerosis Nrf2 Oxidative stress Inflammation Oxidized LDL Lipid metabolism Endothelial cell Smooth muscle cell Macrophage CD36 |
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