A model for the involvement of the small nucleolar RNA (U3) in processing eukaryotic ribosomal RNA |
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| Authors: | R. J. Crouch S. Kanaya P. L. Earl |
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| Affiliation: | 1. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, MD, USA
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| Abstract: | ![]()
The nucleotide sequence of chick pre-rRNA between 5.8S and 28S rRNAs is 85% G + C and has the potential to form many different secondary structures. A model is presented in which a small nucleolar RNA, U3, and its associated proteins act as an RNA isomerase to position the pre-rRNA for processing. Cleavage could be performed either by a nuclease present in the U3RNP or by a ribonuclease directed to the proper form of the pre-rRNA. |
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