| 神经系统中的一氧化氮 |
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| 引用本文： | 高博,尹桂山.神经系统中的一氧化氮[J].生物化学与生物物理进展,1999,26(1):31-34. |
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| 作者姓名： | 高博 尹桂山 |
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| 作者单位： | 河北医科大学生物化学教研室,石家庄,050017 |
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| 摘 要： | 一氧化氮(NO)是一种广泛存在的独特的生物信使因子和效应因子.NO参与脑内许多生理功能和病理生理过程.NO调节神经递质释放和脑血流，参与神经发育和基因表达调控.NO可能作为一种逆行信使物质参与海马的长时程突触传递增强和小脑的长时程突触传递抑制.过多的NO则具有神经毒性并与许多神经系统疾病有关.
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| 关 键 词： | 一氧化氮合酶，神经传导，神经毒性 |
| 收稿时间： | 1997/10/6 0:00:00 |
| 修稿时间： | 3/5/1998 12:00:00 AM |
Nitric Oxide in the Nervous System |
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| GAO Bo and YIN Gui-Shan.Nitric Oxide in the Nervous System[J].Progress In Biochemistry and Biophysics,1999,26(1):31-34. |
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| Authors: | GAO Bo and YIN Gui-Shan |
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| Institution: | Department of Biochemistry,Hebei Medical University,Shijiazhuang 050017,China;Department of Biochemistry,Hebei Medical University,Shijiazhuang 050017,China |
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| Abstract: | Nitric oxide( NO) is a ubiquitous and unique biological messenger molecule and effector.Discoveries have been made regarding the physiologic and pathologic roles of NO in the nervous system.Effects of NO have been identified on neurotrans-mitter release,neural morphogenesis,regulation of gene expression and cerebral blood flow.NO may play a role in long-term potentiation of synaptic transmission in the hippocampus and long-term depression of synaptic transmission in the cerebellum as a retrograde messenger.Excessive production of No is neurotoxic and is implicated in a variety of neurological disorders. |
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| Keywords: | nitric oxide synthase neurotransmission neurotoxicity |
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