Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency |
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| Authors: | Hirofumi Inoue Ken-Ichi Kobayashi Moussa Ndong Yuji Yamamoto Shin-Ichi Katsumata Kazuharu Suzuki |
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| Affiliation: | 1. Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, Tokyo, Japan;2. Department of Applied Biology and Chemistry, Tokyo University of Agriculture, Tokyo, Japan;3. Faculty of Applied Bioscience, Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan |
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| Abstract: | We investigated the effects of dietary iron deficiency on the redox system in the heart. Dietary iron deficiency increased heart weight and accumulation of carbonylated proteins. However, expression levels of heme oxygenase-1 and LC3-II, an antioxidant enzyme and an autophagic marker, respectively, in iron-deficient mice were upregulated compared to the control group, resulting in a surrogate phenomenon against oxidative stress. |
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| Keywords: | iron deficiency heart oxidative stress autophagy antioxidant enzyme |
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