A design for the control of apoptosis in genetically modified Saccharomyces cerevisiae |
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| Authors: | Nao Nishida Misa Noguchi Kouichi Kuroda |
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| Institution: | Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan |
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| Abstract: | We have engineered a system that holds potential for use as a safety switch in genetically modified yeasts. Human apoptotic factor BAX (no homolog in yeast), under the control of the FBP1 (gluconeogenesis enzyme) promoter, was conditionally expressed to induce yeast cell apoptosis after glucose depletion. Such systems might prove useful for the safe use of genetically modified organisms. |
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| Keywords: | apoptosis Saccharomyces cerevisiae genetically modified organism (GMO) Bax gluconeogenesis |
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