Specific features of the apoptotic response of urinary bladder cancer cells to neoadjuvant chemotherapy |
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| Authors: | O I Iatsyna E O Stakhovsky Ya A Sheremet S I Spivak O E Stakhovsky O N Gavrilyuk Yu V Vitruk A I Emets Ya B Blyum S V Vernygorodskyi |
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| Institution: | 1.National Institute of Cancer,Kiev,Ukraine;2.Institute of Food Biotechnology and Genomics,National Academy of Sciences of Ukraine,Kiev,Ukraine |
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| Abstract: | The TUNEL reaction was used to study induced apoptosis in the tumor cells of urinary bladder cancer (UBC) patients. It has
been shown that an increase in the values of induced apoptosis correlates well with the indicators showing a tumor’s corresponding
response to the application of neoadjuvant chemotherapy, using the gemcitabine-cisplatin regimen. It has been concluded that
assessing the level of induced apoptosis in UBC tumor cells using the TUNEL assay enables making a prognosis for the efficacy
of chemotherapy at the single-cell level in patients with this type of cancer. |
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