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Comparative genetic mutation frequencies based on amino acid composition differences
Authors:Vieira Amandio
Affiliation:

aEndocrine & Metabolic Research Laboratory, K9600, Faculty of Applied Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada

Abstract:Genetic variation inferred from large-scale amino acid composition comparisons among genomes and chromosomes of several species, Saccharomyces cerevisiae, Drosophila melanogaster, Ceanorhabditis elegans, H. sapiens, is shown to be correlated (highest, r2 = 0.9855, p < 0.01) with reported mutation rates for various genes in these species. This study, based largely on pseudogene data, helps to establish reference mutation frequencies that are likely to be representative of overall genome mutation rates in each of the species examined, and provides further insight into heterogeneity of mutation rates among genomes.
Keywords:Comparative genomics   Mutation frequencies   Pseudogenes
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