Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase |
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| Authors: | Steere Jennifer A Sampson Peter B Honek John F |
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| Institution: | Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1. |
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| Abstract: | A phosphonic acid analogue of S-adenosyl-L-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase, however each presented distinct kinetic characteristics. |
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