Fine structural localization of acid phosphomonoesterase in the brush border region of osteoclasts |
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| Authors: | Gustav Göthlin Jan L E Ericsson Decent Jan Ericsson |
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| Institution: | (1) Department of Pathology, Sabbatsberg Hospital, Stockholm, Sweden;(2) Department of Orthopedic Surgery, Norrbackainstitutet, Karolinska Institutet Medical School, Stockholm, Sweden;(3) Patologiska institutionen, Sabbatsbergs sjukhus Dalagatan 9-11, Box 6401, S-113 82 Stockholm, Sweden |
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| Abstract: | Summary The fine structural localization of acid phosphomonoesterase was studied in osteoclasts of fracture callus in the rat. In addition to being present in the Golgi apparatus and the lysosomes, reaction product was precipitated over tubular elements, vesicles, and vacuoles located subjacent to the brush border. The findings are compatible with the idea that the calcified matrix can be destroyed by the combined effects of absorption with subsequent intracellular digestions in osteoclasts, and actual secretion of lysosomal enzyme to the extracellular space.This study was supported by grants from the Swedish Medical Research Council (Project no. B72-12X-1006-07A) and  Konung Gustav V:s åttioårsfond". The assistance of Miss Silwa Mengarelli and Mrs. Britt-Marie Åkerman is gratefully acknowledged. |
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