Viral neuraminidase and cellular ectosialyltransferase in human lymphoblastoid cells infected with influenza virus |
| |
| Authors: | M Duc Dodon R Cecchelli R Cacan L Gazzolo A Verbert |
| |
| Affiliation: | 1. Unité de Virologie Fondamentale et Appliquée, I.N.S.E.R.M. (U.51) Groupe de Recherche C.N.R.S. 33, 1, place du Professeur Joseph Renaut, 69371 Lyon Cedex 08, France;7. Laboratoire de Chimie Biologique et Laboratoire Associé au C.N.R.S. n° 217, Université des Sciences et Techniques de Lille, 59655 Villeneuve d''Ascq Cedex, France |
| |
| Abstract: | In human lymphoblastoid cells, infected with an influenza virus, Fowl Plague Virus (FPV), glycoproteins (such as secreted IgM) are hyposialylated, through the action of viral neuraminidase. In this study, the modulation of the cellular ectosialyltransferase activity during viral infection was investigated. This activity was detectable in FPV-infected cells, was shown to be 2.5-fold higher than that of uninfected cells, and to be able to restore, at least partially, the level of sialylation of the cell surface acceptors. |
| |
| Keywords: | sialylation membranaire ectosialyltransférase cell surface sialylation ectosialyltransferase |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
