Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases |
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| Authors: | Saito Fumiyo Takeuchi Ryo Kamino Tomoyuki Kuramochi Kouji Sugawara Fumio Sakaguchi Kengo Kobayashi Susumu |
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| Affiliation: | Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. |
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| Abstract: | We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described. |
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