Non-specific immunity in rabbits infected with 10 strains of the rabbit haemorrhagic disease virus with different biological properties |
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Authors: | Paulina Niedźwiedzka-Rystwej Wiesław Deptuła |
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Institution: | (1) Foreign Animal Disease Diagnostic Laboratory, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, P.O. Box 848, Greenport, NY 11944, USA;(2) Department of Homeland Security, Plum Island Animal Disease Center, P.O. Box 848, Greenport, NY 11944, USA;(3) Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Bianchi, 9, 25124 Brescia, Italy |
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Abstract: | To determine the parameters of non-specific immunity in rabbits infected with 10 biologically different strains of the rabbit
haemorrhagic disease (RHD) virus (BS89, Hagenow, Rainham, Frankfurt, Asturias, Vt97, Triptis, Hartmannsdorf, Pv97, 9905 RHDVa)
the following indices were assessed: polimorphonuclear cell (PMN) adherence capacity, absorption index, percentage of absorbing
cells, spontaneous, stimulated as well as spectrophotometric test for reduction of the nitroblue tetrazolium (NBT), metabolic
activity coefficient of neutrophilic granulocytes, stimulation index, myeloperoxidase activity, lysozyme concentration and
activity index. The symptoms and the percentage of mortality in animals infected were recorded. On the basis of the estimated
parameters, the present study confirmed the existence of immunotypes among the strains of the RHD virus. However, the results
did not indicate a connection between biological property of the RHD virus (haemagglutination capacity and generation of antigenic
variants) and the immunological profile of the strains. |
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