Successive spontaneous abortions including one with whole-arm translocation between chromosomes 2 |
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| Authors: | Koso Ohama Ichiro Kusumi Hiroyuki Takahara Tadashi Kajii |
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| Institution: | (1) Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, Kasumi 1-2-3, Hiroshima, Japan;(2) Genetic and Endocrine Unit, Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York, USA |
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| Abstract: | Summary A family with five induced and seven spontaneous abortions and no live births is described. Four of the seven spontaneous abortuses were available for cytogenetic examination and three were successfully karyotyped. Their karyotypes were 46,XX; 46,XX/46,XX,t(2;2)(2p2p;2q2q); and 46,XY. The karyotypes of the parents were normal. The origin of the 2p/2p and 2p/2p translocation in one of the abortuses was assigned to an interhomologous whole-arm translocation in an early mitotic division in a conceptus with a 46,XX karyotype. |
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