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2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway |
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| Authors: | Han Young-Min Shin Dae-Seop Lee Yu-Jin Ismail Ismail Ahmed Hong Su-Hyung Han Dong Cho Kwon Byoung-Mog |
| Affiliation: | a Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yoosung, Daejeon 305-806, Republic of Korea b University of Science and Technology, 52 Uendong, Yoosung, Daejeon 305-806, Republic of Korea c Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut University, Assiut 71516, Egypt d Department of Dental Microbiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea |
| Abstract: | 2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase. |
| Keywords: | Hydroxycinnamaldehyde Curcuminoid Apoptosis Reactive oxygen species |
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