Enzymatic conversion of deoxycytidine 5'-monophosphate to 5-methyldeoxycytidine 5'-triphosphate |
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| Authors: | R Y Wang L H Huang M Ehrlich |
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| Institution: | Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom |
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| Abstract: | A simple procedure for the synthesis of chiral acetic acids has been developed. The key step is an enzymatic exchange reaction which introduces 3H from 3H-labeled water into ethane 1,2-diol. The method involves no resolution of racemic intermediates and the products are of high specific radioactivity and optical purity. |
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| Keywords: | To whom all correspondence should be addressed |
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