Sodium channel opening as a precursor to inactivation |
| |
Authors: | L Goldman |
| |
Institution: | (1) Department of Physiology, School of Medicine, University of Maryland, 21201 Baltimore, Maryland, USA |
| |
Abstract: | The time constant of the process producing the delay in Na inactivation development as determined by the two pulse method ( delay) was extracted and compared to that of the slowest Na activation process 3 for the I
Na during the conditioning pulse of that same determination. delay and two pulse inactivation c values were computer generated using a nonlinear least squares algorithm. h and single pulse inactivation h values were independently generated for each determination also with the aid of the computer using the same non-linear least squares algorithm. In one determination at 2 mV, c was 4.68 and delay 0.494 ms while h was 4.70 and 3 0.491 ms for a c/ h of 0.996 and a delay/ 3 of 1.006. Mean delay/ 3 from five determinations in four axons, both Cs and K perfused, and spanning a potential range of-27 to 2mV was 1.068. The precursor process to inactivation is channel opening. Some fraction of channels presumably inactivate via another route where prior channel opening is not required. |
| |
Keywords: | Sodium currents inactivation kinetics channel gating |
本文献已被 SpringerLink 等数据库收录! |
|