Protective effect of beta-glucan against systemic Streptococcus pneumoniae infection in mice |
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Authors: | Hetland G Ohno N Aaberge I S Lovik M |
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Institution: | Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway. geir.hetland@folkehelsa.no |
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Abstract: | The antimicrobial effect of soluble beta-1,3-D-glucan from Sclerotinia sclerotiorum (SSG) was examined in mice experimentally infected intraperitoneally (i.p.) with Streptococcus pneumoniae serotypes 4 and 6B. SSG was administered i.p. either 3 days before challenge or 3-48 h after challenge. The number of bacteria in blood samples and the mouse survival rates were recorded. Pre-challenge SSG administration protected dose-dependently against both S. pneumoniae type 4 and 6B infections. SSG injected 24 h post-challenge had a curative effect against type 6B but not type 4 pneumococcal infection. The data demonstrate that SSG administered systemically protects against pneumococcal infection in mice. |
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Keywords: | β-1 3-d-Glucan Antimicrobial effect Streptococcus pneumoniae |
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