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Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences
Authors:Jonathan Coffman  Bruno Marques  Raquel Orozco  Minni Aswath  Hasan Mohammad  Eike Zimmermann  Joelle Khouri  Jan Griesbach  Saeed Izadi  Ambrose Williams  Kannan Sankar  Benjamin Walters  Jasper Lin  Stefan Hepbildikler  John Schiel  John Welsh  Gisela Ferreira  Jared Delmar  Neil Mody  Christopher Afdahl  Tingting Cui  Rushd Khalaf  Alexander Hanke  Lars Pampel  Siddharth Parimal  Xuan Hong  Ujwal Patil  Jennifer Pollard  Francis Insaidoo  Julie Robinson  Divya Chandra  Marco Blanco  Jainik Panchal  Soundara Soundararajan  David Roush  Nihal Tugcu  Steven Cramer  Charles Haynes  Richard C Willson
Institution:1. AstraZeneca, Gaithersburg, Maryland;2. Process Development, Century Therapeutics, Philadelphia, Pennsylvania;3. Boehringer Ingelheim, Fremont, California;4. ProUnlimited supporting Boehringer Ingelheim Fremont Inc., Fremont, California;5. Roche Diagnostics GmbH, Penzberg, Germany;6. Genentech Inc., South San Francisco, California;7. Institute of Bioscience and Biotechnology Research, National Institute of Standards and Technology, Rockville, Maryland;8. Pall Life Sciences, Portsmouth, UK

Department of Biology and Biochemistry, University of Houston, Houston, Texas;9. Novartis, Basel, Switzerland;10. Downstream Process Development, GlaxoSmithKline, King of Prussia, Pennsylvania;11. Protein Design and Informatics, GlaxoSmithKline, Collegeville, Pennsylvania;12. Department of Biology and Biochemistry, University of Houston, Houston, Texas;13. BioProcess Development, MRL, Merck & Co., Inc., Kenilworth, New Jersey;14. Purification Process Development, Sanofi-aventis, Cambridge, Massachusetts;15. Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York;16. Department of Chemical and Biological Engineering, The University of British Columbia, Vancouver, British Columbia, Canada

Abstract:
Keywords:aggregation  chromatography  developability  molecular simulation  purification  QSAR
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