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Manipulation of micro- and nanoparticles in viscoelastic fluid flows within microfluid systems |
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| Authors: | Mohammad K D Manshadi Mehdi Mohammadi Leila Karami Monfared Amir Sanati-Nezhad |
| Institution: | 1. Center for Bioengineering Research and Education, University of Calgary, Calgary, Canada
Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Canada Mohammad K. D. Manshadi and Mehdi Mohammadi contributed equally to this study.;2. Center for Bioengineering Research and Education, University of Calgary, Calgary, Canada;3. Department of Mechanical Engineering, Yazd University, Yazd, Iran |
| Abstract: | Manipulation of micro- and nanoparticles in complex biofluids is highly demanded in most biological and biomedical applications. A significant number of microfluidic platforms have been developed for inexpensive, rapid, accurate, and efficient particle manipulation. Due to the enormous potential of viscoelastic fluids (VEFs) for particle manipulation, various emerging microfluidic-based VEFs techniques have been presented over the last decade. This review provides an intuitive understanding of VEF physics for particle separation in different microchannel geometries. Besides, active and passive VEF methods are critically reviewed, highlighting the potential and practical challenges of each technique for particle/cell focusing, sorting, and separation. The outcome of this study could enable recognizing deliverable VEF technology with the promising prospect in the manipulation of submicron biological samples (e.g., exosomes, DNA, and proteins). |
| Keywords: | cell/particle separation microfluidics particle/cell manipulation passive and active viscoelastic methods viscoelastic fluid |