| 生物膜信号转导与细胞凋亡 |
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| 引用本文： | 辛宏,颜光涛,陈泮藻.生物膜信号转导与细胞凋亡[J].生物化学与生物物理进展,2001,28(1):52-55. |
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| 作者姓名： | 辛宏 颜光涛 陈泮藻 |
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| 作者单位： | 解放军总医院基础医学研究所生化研究室, |
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| 摘 要： | 胞外信号可经过相应的转导途径传至胞内，通过激活靶分子而产生细胞效应.细胞凋亡是受控于生物体精确调节的细胞主动消亡过程，具有独特而复杂的信号系统.特异性的胞膜蛋白及膜脂等皆可介导凋亡相关分子的级联激活，并通过活化凋亡关键调节分子Caspases蛋白酶家族，bcl-2基因家族及线粒体等而影响凋亡的进程.
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| 关 键 词： | 凋亡，Caspases蛋白酶，bcl-2，线粒体 |
| 收稿时间： | 2/2/2000 12:00:00 AM |
| 修稿时间： | 2000年2月2日 |
Biomembrane Signal Transduction and Apoptosis |
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| XIN Hong,YAN Guang-Tao and CHEN Ban-Zao.Biomembrane Signal Transduction and Apoptosis[J].Progress In Biochemistry and Biophysics,2001,28(1):52-55. |
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| Authors: | XIN Hong YAN Guang-Tao and CHEN Ban-Zao |
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| Institution: | Biochemistry Laboratry of the PLA General Hospital, Beijing 100853, China;Biochemistry Laboratry of the PLA General Hospital, Beijing 100853, China;Biochemistry Laboratry of the PLA General Hospital, Beijing 100853, China |
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| Abstract: | A variety of extra-cellular signals could activate the target molecules and induce the associated biological effects depended on different signal pathways. Apoptosis,or programmed cell death, is a conservation process essential for normal development and homeostasis of biologist. It's known that a number of factors and pathways can lead to apoptosis. Specific phosphorlipids and proteins of biomembrane could activate the signal cascades of apoptosis. The interaction of caspases, bcl-2 family and mitochondria play an essential role in regulation of apoptosis. |
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| Keywords: | apoptosis caspase bcl 2 gene mitochondria |
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