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Synthesis and Immunostimulating Properties of Novel Adamant‐1‐yl Tripeptides |
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| Authors: | Rosana Ribi? Lidija Habjanec Branka Vrane?i? Ru?a Frkanec Sr?anka Tomi? |
| Institution: | 1. Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR‐10000 Zagreb, Croatia;2. Institute of Immunology, Rockfellerova 2, HR‐10000, Zagreb, Croatia (phone: +385?1?6414?380;3. fax: +385?1?6414?103) |
| Abstract: | The aim of this work was to prepare L ‐ and D ‐(adamant‐1‐yl)‐Gly‐L ‐Ala‐D ‐isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant‐1‐yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β‐D ‐GlcNAc‐(1→4)‐D ‐MurNAc‐L ‐Ala‐D ‐isoGln‐mesoDAP(εNH2)‐D ‐Ala‐D ‐Ala) and structurally related adamant‐2‐yl tripeptides. |
| Keywords: | Adamantyl tripeptides Immunostimulating activity Peptides Peptidoglycans |