Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread |
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| Authors: | Ammad Ahmad Farooqi Ali Naqi Muhammad Zahid Qureshi Aamir Rana Ammara Khan Asma M Riaz Syed Muhammad Faheem Afzal Nabeelah Rasheed Shahzad Bhatti |
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| Institution: | 1. Lab for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, , Lahore, Pakistan;2. Institute of Molecular Biology and Biotechnology, The University of Lahore, , Lahore, Pakistan;3. Biochemistry Lab, Department of Chemistry, G C University, , Lahore, Pakistan;4. NUST Centre of Virology and Immunology, National University of Science and Technology, , Islamabad, Pakistan |
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| Abstract: | Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis. Unswervingly, these elements constitute a recently explored ‘network of networks’ that dynamically reorganizes during DNA damage and is responsible for positively or negatively regulating genome organization and integrity. We consider these facets of convergence and discuss how insights from diametrically opposed interactions of ataxia–telangiectasia mutated and mitrons can inform us about, and possibly help us to get a step closer to personalized medicine. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | prostate cancer miRNA oncomirs therapeutic interventions signalling cascade |
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