Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14‐3‐3 epsilon |
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| Authors: | William K. K. Wu Minyi He Liang Zhao Xuegang Sun Hui Li Yong Jiang Yungao Yang Kang Peng |
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| Affiliation: | 1. Institute of Digestive Diseases, LKS Institute of Health Sciences and Department of Medicine & Therapeutics, The Chinese University of Hong Kong, , Hong Kong, China;2. Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, , Guangzhou, China;3. Key Laboratory of Transcriptome and Proteome of Human Diseases Supported by Guangdong Province and the Ministry of China, Southern Medical University, , Guangzhou, China;4. School of Traditional Chinese Medicine, Southern Medical University, , Guangzhou, China;5. Guangzhou Promoter Biotechnology Limited Corporation, , Guangzhou, China |
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| Abstract: | Triptolide is a diterpenoid triepoxide derived from the traditional Chinese medical herb Tripterygium wilfordii. In the present study, we demonstrated that this phytochemical attenuated colon cancer growth in vitro and in vivo. Using a proteomic approach, we found that 14‐3‐3 epsilon, a cell cycle‐ and apoptosis‐related protein, was altered in colon cancer cells treated with triptolide. In this regard, triptolide induced cleavage and perinuclear translocation of 14‐3‐3 epsilon. Taken together, our findings suggest that triptolide may merit investigation as a potential therapeutic agent for colon cancer, and its anticancer action may be associated with alteration of 14‐3‐3 epsilon. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | triptolide colorectal cancer 14‐3‐3 epsilon proteomics |
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