The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy‐induced and radiotherapy‐induced toxicity |
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| Authors: | Sumeyya Akyol Zeynep Ginis Ferah Armutcu Gulfer Ozturk M. Ramazan Yigitoglu Omer Akyol |
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| Affiliation: | 1. Department of Biochemistry, Fatih University Medical School, , Ankara, Turkey;2. Department of Clinical Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, , Ankara, Turkey;3. Department of Biochemistry, Hacettepe University Medical School, , Ankara, Turkey;4. Department of Chemistry, Ankara Branch of Council of Forensic Medicine, , Ankara, Turkey |
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| Abstract: | Protection of the patients against the side effects of chemotherapy and radiotherapy regimens has attracted increasing interest of clinicians and practitioners. Caffeic acid phenethyl ester (CAPE), which is extracted from the propolis of honeybee hives as an active component, specifically inhibits nuclear factor κB at micromolar concentrations and show ability to stop 5‐lipoxygenase‐catalysed oxygenation of linoleic acid and arachidonic acid. CAPE has antiinflammatory, antiproliferative, antioxidant, cytostatic, antiviral, antibacterial, antifungal and antineoplastic properties. The purpose of this review is to summarize in vivo and in vitro usage of CAPE to prevent the chemotherapy‐induced and radiotherapy‐induced damages and side effects in experimental animals and to develop a new approach for the potential usage of CAPE in clinical trial as a protective agent during chemotherapy and radiotherapy regimens. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | caffeic acid phenethyl ester (CAPE) antineoplastic side effect cancer treatment |
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