Genomic linkage map of the human blood fluke Schistosoma mansoni |
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| Authors: | Charles D Criscione Claudia LL Valentim Hirohisa Hirai Philip T LoVerde Timothy JC Anderson |
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| Institution: | (1) Department of Biology, Texas A&;M University, College Station, TX 77843, USA;(2) Departments of Biochemistry and Pathology, University of Texas Health Science Center, San Antonio, Texas 78229, USA;(3) Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA;(4) Primate Research Institute, Kyoto University, Inuyama Aichi, 484-8506, Japan |
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| Abstract: | Background
Schistosoma mansoni is a blood fluke that infects approximately 90 million people. The complete life cycle of this parasite can be maintained
in the laboratory, making this one of the few experimentally tractable human helminth infections, and a rich literature reveals
heritable variation in important biomedical traits such as virulence, host-specificity, transmission and drug resistance.
However, there is a current lack of tools needed to study S. mansoni's molecular, quantitative, and population genetics. Our goal was to construct a genetic linkage map for S. mansoni, and thus provide a new resource that will help stimulate research on this neglected pathogen. |
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