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PGC-1 Coactivators Regulate MITF and the Tanning Response
Authors:Jonathan Shoag  Rizwan Haq  Mingfeng Zhang  Laura Liu  Glenn C Rowe  Aihua Jiang  Nicole Koulisis  Caitlin Farrel  Christopher I Amos  Qingyi Wei  Jeffrey E Lee  Jiangwen Zhang  Thomas S Kupper  Abrar A Qureshi  Rutao Cui  Jiali Han  David E Fisher  Zoltan Arany
Institution:1. Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA;2. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA;3. Departments of Medicine and Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;4. Division of Health Sciences and Technology, MIT and Harvard Medical School, Cambridge, MA 02139, USA;5. Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA;6. Research Computing, Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA;7. Department of Epidemiology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA;8. Department of Surgical Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA;9. Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA;10. Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA;11. Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Abstract:
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  • Highlights? PGC-1 induces pigment formation in melanocytes ? PGC-1s activate expression of MITF ? α-MSH induces PGC-1s, which are required for induction of melanogenic genes ? eQTLs in human PGC-1β are associated with tanning ability and melanoma protection
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