| 肝再生刺激因子对小鼠实验性急性肝损伤的保护作用 |
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| 引用本文： | 安威,梅懋华.肝再生刺激因子对小鼠实验性急性肝损伤的保护作用[J].生理学报,1991(5). |
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| 作者姓名： | 安威 梅懋华 |
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| 作者单位： | 大连医学院生理学教研室 大连116023
(安威)，大连医学院生理学教研室 大连116023(梅懋华) |
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| 摘 要： | 本工作采用雄性初断乳 SD 大鼠肝按 LaBrecque 法提取肝再生刺激因子(HSS),用四氯化碳和半乳糖胺分别损伤小鼠肝来研究 HSS 的保肝作用。结果如后:(1)HSS 可使 CCl_4致肝损伤小鼠的血清 GPT 和 GOT 升高幅度降低,并呈量效关系。(2)肝组织切片表明 HSS 可使 CCl_4损伤肝组织的程度减轻。(3)肝组织化学法表明 HSS 可使 CCl_4损害肝细胞线粒体琥珀酸脱氢酶的活性恢复。(4)胰岛素-胰高糖素可降低半乳糖胺所致的小鼠死亡率,减弱对肝组织的损害和刺激肝细胞增殖,这项实验可作为 HSS 具有保肝作用的证据。
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| 关 键 词： | 肝再生刺激因子 四氯化碳 半乳糖胺 胰岛素-胰高糖素 保肝作用 |
PROTECTIVE EFFECT OF HEPATIC STIMULATOR SUBSTANCE AGAINST EXPERIMENTAL ACUTE LIVER FAILURE IN MICE |
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| AN WEI,MEI MAO-HUA.PROTECTIVE EFFECT OF HEPATIC STIMULATOR SUBSTANCE AGAINST EXPERIMENTAL ACUTE LIVER FAILURE IN MICE[J].Acta Physiologica Sinica,1991(5). |
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| Authors: | AN WEI MEI MAO-HUA |
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| Abstract: | A hepatic stimulator substance(HSS)was extracted from the liver of maleweanling SD rats according to the method of LaBrecque.The mice were in-jected with carbon tetrachloride or D-galactosamine to induce hepatic injuriesand the protective effect of HSS on thus induced hepatic damage was investi-gated.The results were as follows:(1)HSS could suppresses the elevation of sGPTand sGOT induced by carbon tetrachloride intoxication in a dose-dependentmanner.(2)Hepatic histological findings indicated that the degree of CCl_4 orD-galactosamine-induced hepatic lesions could be lessened by HSS.(3)CCl_4-induced reduction of hepatic mitochondrial succinic dehydrogenase activitycould be restored by HSS.(4)Insulin-glucagon enhanced the survival of D-galactosamine intoxicated mice and stimulated hepatocyte proliferation,thusshowing less pronounced hepatic damage. |
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| Keywords: | hepatic stimulator substance(HSS) carbon tetrachloride(CCl_4) D-galactosamine insulin-glucagon liver protection |
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