|
|||||
|
|
Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans |
|
| Authors: | Albert Frank W Shchepina Olesya Winter Christine Römpler Holger Teupser Daniel Palme Rupert Ceglarek Uta Kratzsch Jürgen Sohr Reinhard Trut Lyudmila N Thiery Joachim Morgenstern Rudolf Plyusnina Irina Z Schöneberg Torsten Pääbo Svante |
| Institution: | a Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany b Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia c Department of Psychiatry and Psychotherapy, University Medicine Berlin, Charité Campus Mitte, Berlin, Germany d Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany e Museum of Comparative Zoology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA f Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany g Institute of Biochemistry, Department of Natural Sciences, University of Veterinary Medicine, Vienna, Austria h Institute of Pharmacology and Toxicology, University Medicine Berlin, Charité Campus Mitte, Berlin, Germany i Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden |
| Abstract: | To better understand the biology of tameness, i.e. tolerance of human presence and handling, we analyzed two lines of wild-derived rats (Rattus norvegicus) artificially selected for tameness and defensive aggression towards humans. In response to a gloved human hand, tame rats tolerated handling, whereas aggressive rats attacked. Cross-fostering showed that these behavioral differences are not caused by postnatal maternal effects. Tame rats were more active and explorative and exhibited fewer anxiety-related behaviors. They also had smaller adrenal glands, larger spleens and lower levels of serum corticosterone. Blood glucose levels were lower in tame rats, whereas the concentrations of nine amino acids were higher. In the brain, tame rats had lower serotonin and higher taurine levels than aggressive rats. Our findings reinforce the notion that tameness is correlated with differences in stress response and will facilitate future efforts to uncover the genetic basis for animal tameness. |
| Keywords: | Domestication Behavior Corticosterone Anxiety Taurine Serotonin |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |