Notch信号途径及其调控

Notch是一个进化上十分保守的跨膜受体蛋白家族，对无脊椎动物和脊椎动物发育过程中的细胞命运决定起重要作用。一条重要的Notch信号途径涉及Notch的“三步蛋白质水解”活化。许多相关分子和体内生化过程参与Notch信号途径调控。调控发生在不同水平，包括Notch-配体互作、受体和配体的运输、泛素化降解等。现就Notch受体、Notch信号途径及其所受的不同水平的调控进行综述。

Notch Signaling Pathway and Its Regulation

The Notch receptor is an evolutionarily conserved single-span transmembrane protein family and plays key roles in a wide variety of cell fate decisions during development of both invertebrate and vertebrate species. An intriguing pathway of Notch signaling has been elucidated involving three-step proteolytic cleavages leading to activation of Notch. A number of molecules related and events in vivo have been identified to regulate Notch signaling. Regulation occurs at multiple levels including Notch-ligand interactions, trafficking of receptor and ligands, the cleavage of Notch intracellular, degradation of proteins by ubiquitination, and so on. This review focuses on the Notch receptor, Notch signaling pathway and its regulation at different levels.