Respiratory control and mitochondrial monovalent cation permeability of isolated liver cells |
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Authors: | W P Dubinsky R S Cockrell |
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Institution: | Department of Biochemistry St. Louis University School of Medicine St. Louis, Mo. 63104 USA |
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Abstract: | Uncoupling agent releases the respiratory control of rat hepatocytes to approximately the same degree as in isolated mitochondria indicating that mitochondria possess a low H+ conductance as . Mitochondria also have no detectable natural K+ conductance since the ionophore, valinomycin, is required for K+ ions to uncouple. Na+ but not K+ or choline inhibits the uncoupled respiration of liver cells. This is consistent with operation of neutral mitochondrial Na+ for H+ exchange . These results indicate a considerable similarity between certain functional and permeability properties of mitochondria and . These similarities form the basis for discussion of the role of mitochondrial ion transport in metabolic regulation. |
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