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A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats
Authors:E L Tolman  L E Metzger  L S Jefferson
Affiliation:1. School of Nursing, Beijing University of Chinese Medicine, No.11, Beisanhuandonglu, Chaoyang District, Beijing, China;2. Beijing University of Chinese Medicine Collaborating Center of Joanna Briggs Institute, No.11, Beisanhuandonglu, Chaoyang District, Beijing, China;3. Beijing University of Chinese Medicine Best Practice Spotlight Organization, No.11, Beisanhuandonglu, Chaoyang District, Beijing, China;1. School of Transportation, Southeast University, 211189, PR China;2. School of Automobile and Transportation Engineering, Hefei University of Technology, 230009, PR China;3. Department of Civil Engineering, Ryerson University, Toronto, ON M5B 2K3, Canada;4. Department of Civil and Environmental Engineering, Nanyang Technological University, Singapore;5. Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada
Abstract:
Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.
Keywords:
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