The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography |
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| Authors: | F Garmendia G L Nicolis J L Gabrilove |
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| Affiliation: | 1. Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste-Catherine Road, Montreal, QC, H3T 1E2, Canada;2. Alberta Precision Laboratories – Calgary and Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada;1. Amsterdam Institute for Life and Environment (A-LIFE), Faculty of Science, Vrije Universiteit Amsterdam, the Netherlands;2. GREEN Tox and Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland;3. Departments of Physiology and of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain |
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| Abstract: | ![]()
Pregnanetriol (pregnane-3α, 17, 20α-triol (PT), androsterone (3α-hydroxy-5α-androstan-17-one)(A), etiocholanolone (3α-hydroxy-5β-androstan-17-one) (E) and dehydroepiandrosterone (3β-hydroxy-androst-5-en-17-one) (DHEA) were determined in the urine of fifty five subjects using gas liquid chromatography. Increased titers of urinary pregnanetriol were encountered in nine patients with the non-tumorous form of the adrenogenital syndrome, in three of four patients with Cushing's syndrome due to adrenal hyperplasia, in three patients with “idiopathic” hirsutism. Normal titers were found in a patient with Cushing's syndrome due to an adrenal adenoma, in six of seven patients with idiopathic hirsutism and in eleven patients with various other endocrinopathies. In three patients with adrenal insufficiency urinary pregnanetriol was low. |
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