Identification of the MHC class I B locus in cynomolgus monkeys |
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| Authors: | Akihiko Uda Kiyoshi Tanabayashi Osamu Fujita Akitoyo Hotta Keiji Terao Akio Yamada |
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| Affiliation: | (1) Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan;(2) Tsukuba Primate Center for Medical Science, National Institute of Infectious Diseases, 1 Hachimandai, Tsukuba, Ibaraki 305-0843, Japan |
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| Abstract: | ![]()
By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys. |
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| Keywords: | Cynomolgus MHC Mafa Allele |
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