Experimental antimony toxicity on lower motor neurons and muscles of mice |
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| Affiliation: | 1. Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada;2. Alberta Centre for Toxicology, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada;3. MOE Key Laboratory of Aquatic Product Safety, School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510275, China;4. Department of Chemistry, Brock University, St. Catharines, Ontario L2S 3A1, Canada;5. Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4L8, Canada |
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| Abstract: | The occurrence of muscular weakness and wasting in patients with schistosomal infections treated with tartar emetic prompted this investigation of the role of antimony (potassium tartrate) on the lower motor neurons and muscle of mice (lumbar cord, sciatic nerve, myoneural junction, and gastrocnemius). Motor weakness could be demonstrated in the animals and could be correlated with the dosage by testing muscle endurance in an activity cage. The pathological changes in the anterior horn cells are vacuolar degeneration, chromatolysis, satellitosis, and swelling of the nuclei. The edematous sciatic nerves have hydropic degeneration with vacuolation, and fragmentation of axons. The myoneural junctions show swollen ramifications of the axis cylinder and an increase in the number of end-plate nuclei. Some muscle fibers (gastrocnemius) have hyaline and granular alterations with vesicular nuclei, and other atrophic fibers with pyknotic nuclei, but the main changes are in the anterior horn cells, sciatic nerves, and myoneural junction. |
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