实验兔接种兔病毒性出血症病毒疫苗后的免疫应答

IMMUNE RESPONSE TO VIRAL HEMORRHAGIC DISEASE OF RABBIT

Studies on the immune indices of rabbits inoculated with rabbit hemorr-hagic disease virus ( RHDV ) vaccine and challenged with virulent virus indicated that actively produced or passively transferred antibodies could protect rabbits from RHDV-challenge. Stimulation index (SI) of lymphocyte transformation increased only at the 17th day and specific transfer factor of rabbit ( RSTF ) had little protective effect. Thus, humoral immunity plays an important role in protection against viral hemorrhagic disease.Interferon ( IFN ) was induced immediately by poly I:C in vivo and could protect rabbits against RHDV infection. RHDV vaccine also induced IFN , IFN could also be produced in rabbits infected with the virulent virus, but the titers in rabbits which died from the infection were significantly lower than that reached in one recovered rabbit. It is suggested that IFN may take a part in the immune mechanism of RHDV vaccine and is involved in the early protection and perhaps in recovery from viral hemmorhagic disease.