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The distribution of the Hb Constant Spring gene in Southeast Asian populations |
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| Authors: | Marion Laig Michael Pape Joachim Hundrieser Gebhard Flatz Torpong Sanguansermsri B M Das Ranjan Deka Puangrat Yongvanit Naret Mularlee |
| Institution: | (1) Abteilung Humangenetik, Medizinische Hochschule, Postfach 610180, D-3000 Hannover, 61, Germany;(2) Human Genetics Unit, Faculty of Medicine, Chiangmai University, Chiangmai, Thailand;(3) Department of Anthropology, Gauhati University, Guwahati, India;(4) Department of Anthropology, Dibrugarh University, Dibrugarh, India;(5) Department of Biochemistry, Faculty of Medicine, Khonkaen University, Khonkaen, Thailand;(6) Department of Biology, Faculty of Science, Khonkaen University, Khonkaen, Thailand;(7) Present address: Department of Biostatistics, University of Pittsburgh, 15261 Pittsburgh, PA, USA |
| Abstract: | Summary The distribution of the hemoglobin Constant Spring (Hb CS) gene in eight populations in Southeast Asia (including Assam) was determined using oligonucleotide hybridization. Hb CS was absent in two Assamese populations with a high prevalence of Hb E. The Hb CS gene frequency was 0.033 in northern Thailand and near 0.01 in central Thailand and Cambodia. High frequencies, between 0.05 and 0.06, were observed in northeastern Thailand. The present data and a similar study in Laotians suggest that the Lao-speaking populations of the Mekong River basin in northeastern Thailand and Laos have the highest frequencies of the Hb CS gene in Southeast Asia. |
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