大肠癌组织中TS和COX-2的表达及其与患者无病生存期的关系

目的:探讨大肠癌患者癌组织中环氧化酶-2(COX-2)、胸苷酸合成酶(TS)的表达及其与患者无病生存期的关系。方法:筛选我院收治的大肠癌根治术患者,选择无病生存期大于48个月者30例和无病生存期小于48个月者29例。采用免疫组化法检测大肠癌组织中COX-2和TS的表达,并分析其与患者无病生存期的关系。结果:49例结直肠癌患者中,TS的阳性表达率为91.84%,COX-2的阳性表达率为77.55%。不同无病生存期的大肠癌患者TS的表达水平比较无统计学差异(P=0.646)。COX-2在无病生存期48个月的患者癌组织中表达水平明显低于无病生存期48个月的患者,差异有统计学意义(P=0.033)。结论:COX-2与大肠癌患者的无病生存期显著相关,可能成为预测大肠癌预后的参考指标。

Relationship between the DFS and Expression of TS, COX-2 in Colorectal Cancer

Objective:To investigate the correlation of cyclooxygenase-2 (COX-2) and thymidylate synthase (TS) expressions in Cancerous tissue with the disease free survival of patients with colorectal cancer.Methods:30 patients with colorectal cancer whose disease-free survival were more than 48 months and 29 patients with colorectal cancer whose disease-free survival were less than 48 months were selected and underwent radical surgery in our hospital. The expression of COX-2 and TS in Cancerous tissue were detected by immunohistochemistry, the relationship between them and disease-free survival were analyzed.Results:In 49 patients with colorectal cancer, the positive expreesion rate of TS and COX-2 were 91.84% and 77.55%, respectivly. No significant difference was found in the expression of TS between the patients with different disease-free survival (P=0.646). The expression of COX-2 of patients whose DFS were longer than 48 months were significantly lower than those whose DFS were shorter than 48 months (P=0.033).Conclusion:COX-2 was significantly related to the disease-free survival of patients with colorectal cancer, which might be a marker to predict the prognosis of colorectal cancer.