环境雌激素双酚A的研究进展

环境荷尔蒙是现代生命科学领域研究的热点之一,如今越来越多的人开始关注这一话题。在我们的生活环境中充斥着各种化学有毒试剂,其中,有一类物质能够模拟或抑制内分泌激素的活动,我们称之为内分泌干扰物。内分泌干扰物有能力改变内分泌系统的结构和功能。双酚A作为一种环境雌激素,属于内分泌干扰物的一种。双酚A被广泛应用于聚碳酸酯塑料和环氧树脂的制造。双酚A具有弱雌激素效应,能够与雌激素受体结合,引起内分泌系统的应答。目前的研究表明,双酚A会透过血胎屏障影响到胚胎发育,会对神经内分泌系统、肝组织功能以及生殖器的发育造成损伤。本文主要综述了环境雌激素双酚A在小鼠发育阶段所引起的诸多不利影响,并对环境荷尔蒙未来的研究方向进行了展望。

The Research Progress of Environmental Estrogen Bisphenol A

Environmental hormones is one of the hot spots in the modern life science research. Nowadays more and more peoplebegin to pay attention to this topic. It is filled with a variety of chemical toxic reagents in our living environment. Among them, there''s aclass of substances which can simulate or inhibit hormone activity, called endocrine disruptors. Endocrine disruptors have the ability tochange the structure and function of the endocrine system. Bisphenol A is an environmental estrogen, which belongs to one of endocrinedisruptors. Bisphenol A is widely used in the manufacture of polycarbonate plastic and epoxy resins. Bisphenol A has a weak estrogeniceffect and can bind to estrogen receptors, causing the endocrine system response. The present study shows that bisphenol A affect embryonic development cross the blood placental barrier and damage the neuroendocrine system, liver function and reproductive development.This paper summarizes many adverse effects caused by the environmental estrogen bisphenol A during developmental stage in mice anddiscusses the research direction of environmental hormones in the future.