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Embryonic skin development and repair |
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| Authors: | Michael S. Hu Mimi R. Borrelli Wan Xing Hong Samir Malhotra Alexander T. M. Cheung Ryan C. Ransom |
| Affiliation: | 1. Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine, Stanford, California;2. Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California |
| Abstract: | Fetal cutaneous wounds have the unique ability to completely regenerate wounded skin and heal without scarring. However, adult cutaneous wounds heal via a fibroproliferative response which results in the formation of a scar. Understanding the mechanism(s) of scarless wound healing leads to enormous clinical potential in facilitating an environment conducive to scarless healing in adult cutaneous wounds. This article reviews the embryonic development of the skin and outlines the structural and functional differences in adult and fetal wound healing phenotypes. A review of current developments made towards applying this clinical knowledge to promote scarless healing in adult wounds is addressed. |
| Keywords: | wound healing fetal wound healing scarless regeneration scarring embryogenesis cutaneous |